Med Hypotheses. 2000 Jun;54(6):979-83.
Is autism a G-alpha protein defect reversible
with natural vitamin A?
Pediatric and Adolescent Ability Center, Richmond,
VA 23226, USA.
Autism may be a disorder linked to the disruption
of the G-alpha protein, affecting retinoid receptors
in the brain. A study of 60 autistic children suggests
that autism may be caused by inserting a G-alpha
protein defect, the pertussis toxin found in the
DPT vaccine, into genetically at-risk children. This
toxin separates the G-alpha protein from retinoid
receptors. Those most at risk report a family history
of at least one parent with a pre-existing G-alpha
protein defect, including night blindness, pseudohypoparathyroidism
or adenoma of the thyroid or pituitary gland.Natural
vitamin A may reconnect the retinoid receptors critical
for vision, sensory perception, language processing
and attention. Autism spectrum disorders have increased
from 1 in 10 000 in 1978 to 1 in 300 in some US communities
in 1999. Recent evidence indicates that autism is
a disorder of the nervous system and the immune system,
affecting multiple metabolic pathways.
Pediatr Neurol. 2003 Apr;28(4):292-4.
Elevated levels of measles antibodies in
children with autism.
Department of Biology and Biotechnology Center,
Utah State University, Logan, Utah, USA.
Virus-induced autoimmunity may play a causal role
in autism. To examine the etiologic link of viruses
in this brain disorder, we conducted a serologic
study of measles virus, mumps virus, and rubella
virus. Viral antibodies were measured by enzyme-linked
immunosorbent assay in the serum of autistic children,
normal children, and siblings of autistic children.
The level of measles antibody, but not mumps or rubella
antibodies, was significantly higher in autistic
children as compared with normal children (P = 0.003)
or siblings of autistic children (P <or= 0.0001).
Furthermore, immunoblotting of measles vaccine virus
revealed that the antibody was directed against a
protein of approximately 74 kd molecular weight.
The antibody to this antigen was found in 83% of
autistic children but not in normal children or siblings
of autistic children. Thus autistic children have
a hyperimmune response to measles virus, which in
the absence of a wild type of measles infection might
be a sign of an abnormal immune reaction to the vaccine
strain or virus reactivation